Last update :
28/04/2024
References   References 822  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Zhang Y, Trissel LA, Martinez JF, Gilbert DL.
Title : Stability of acyclovir sodium 1, 7, and 10 mg/ml in 5% dextrose injection and in 0.9% sodium chloride injection.
Reference : Am J Health-Syst Pharm ; 55: 574-577. 1998

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionAciclovir sodium Antiviral
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 7 & 10 mg/ml 4°C Protect from light
35 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 7 & 10 mg/ml 23°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Glucose 5% 1 & 7 & 10 mg/ml 23°C Protect from light
21 Day

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