Last update :
16/06/2024
References   References 747  
Type : Journal

Research teams : Philadelphia - Smith Kline and French Laboratories
Authors : Rosenberg HA, Dougherty JT, Mayron D, Baldinus JG.
Title : Cimetidine hydrochloride compatibility. I: Chemical aspects and room temperature stability in intravenous infusion fluids.
Reference : Am J Hosp Pharm ; 37: 390-392. 1980

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionCimetidine hydrochloride Antihistamine (H2)
Stability in solutions Glass Sodium chloride 0,9% 1,2 & 5 mg/ml 25°C Light
7 Day
Stability in solutions Glass Glucose 5% 1,2 & 5 mg/ml 25°C Light
7 Day
Stability in solutions Glass Ringer’s lactate solution 1,2 & 5 mg/ml 25°C Light
7 Day
Stability in solutions Glass Glucose 10% 1,2 & 5 mg/ml 25°C Light
7 Day
Stability in solutions Polyvinyl chloride Glucose 5% 1,2 & 5 mg/ml 25°C Light
7 Day
Stability in solutions Polyvinyl chloride Glucose 10% 1,2 & 5 mg/ml 25°C Light
7 Day

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