Last update :
18/04/2024
References   References 695  
Type : Journal

Research teams : Salt Lake City - University of Utah Health Care, Department of Pharmacy Services
Authors : Zbrozek AS, Marble DA, Bosso JA.
Title : Compatibility and stability of cefazolin sodium, clindamycin phosphate, and gentamicin sulfate in two intravenous solutions.
Reference : Drug Intell Clin Pharm ; 22: 873-875. 1988

Level of Evidence : 
Joker
Level of Evidence : 
Level of evidence B Clindamycin phosphate
Level of evidence D Cefazolin sodium
Biological analysis Gentamicin sulfate
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
No comments for the degradation products

List of drugs
InjectionCefazolin sodium Antibiotic
InjectionClindamycin phosphate Antibiotic
InjectionGentamicin sulfate Antibiotic
Stability of mixtures
Glass Sodium chloride 0,9% 25°C Light
Injection Cefazolin sodium 10 mg/ml
Injection Clindamycin phosphate 9 mg/ml
Injection Gentamicin sulfate 0,8 mg/ml
12 Hour
Glass Glucose 5% 25°C Light
Injection Cefazolin sodium 10 mg/ml
Injection Clindamycin phosphate 9 mg/ml
Injection Gentamicin sulfate 0,8 mg/ml
1 Hour

  Mentions Légales