Last update :
03/05/2024
References   References 60  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/47/9/2037

Research teams : Oklahoma City - University of Oklahoma Health Sciences Center, College of Pharmacy
Authors : Tu YH, Stiles ML, Allen LV Jr.
Title : Stability of fentanyl citrate and bupivacaine hydrochloride in portable pump reservoirs.
Reference : Am J Hosp Pharm ; 47: 2037-2040. 1990

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionBupivacaine hydrochloride Local anesthetic
Compatible 1,250 mg/ml + InjectionFentanyl citrate 20 µg/ml + Sodium chloride 0,9%
InjectionFentanyl citrate Analgesic
Compatible 20 µg/ml + InjectionBupivacaine hydrochloride 1,250 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 23°C With or without light
Injection Bupivacaine hydrochloride 1,250 mg/ml
Injection Fentanyl citrate 20 µg/ml
30 Day
Polyvinyl chloride Sodium chloride 0,9% 3°C With or without light
Injection Fentanyl citrate 20 µg/ml
Injection Bupivacaine hydrochloride 1,250 mg/ml
30 Day

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