Last update :
16/06/2024
References   References 589  
Type : Journal

Research teams : Nancy - Faculté des sciences pharmaceutiques et biologiques
Authors : Kedzierewicz F, Finance C, Nicolas A, Dixneuf P, Hoffman M.
Title : Stability of parenteral ceftriaxone disodium solutions in frozen and liquid states: effect of freezing and microwave thawing.
Reference : J Pharm Sci ; 78: 73-77. 1989

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
InjectionCeftriaxone disodium Antibiotic
Factors which affect stability Solvent Glucose 5% Induces Enhanced stability
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 & 50 mg/ml -20°C Protect from light
182 Day
Stability in solutions Glass Sodium chloride 0,9% 10 mg/ml 5°C Protect from light
21 Day
Stability in solutions Glass Sodium chloride 0,9% 10 & 50 mg/ml 15°C-32°C Not specified
7 Day
Stability in solutions Glass Sodium chloride 0,9% 50 mg/ml 5°C Protect from light
35 Day
Stability in solutions Glass Glucose 5% 10 mg/ml 15°C-32°C Not specified
7 Day
Stability in solutions Glass Glucose 5% 10 mg/ml 5°C Protect from light
84 Day
Stability in solutions Glass Glucose 5% 50 mg/ml 15°C-32°C Not specified
24 Hour
Stability in solutions Glass Glucose 5% 50 mg/ml 5°C Protect from light
56 Day

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