Last update :
08/12/2024
References   References 561  
Type : Journal

Research teams : Syracuse - Bristol Laboratories, Product Development R
Authors : Nunning BC, Granatek AP.
Title : Physical compatibility and chemical stability of amikacin sulfate in large-volume parenteral solutions. Part II.
Reference : Current Ther Res ; 20: 359-368. 1976

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
The method is not specified (poster, letter to the editor)
Increased concentration unexplained
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products

List of drugs
injectionAmikacin sulfate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,25 & 5 mg/ml -15°C Protect from light
30 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,25 & 5 mg/ml 25°C Not specified
24 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,25 & 5 mg/ml 4°C Protect from light
60 Day
Stability in solutions Glass Ringer’s lactate solution 0,25 & 5 mg/ml -15°C Protect from light
30 Day
Stability in solutions Glass Ringer’s lactate solution 0,25 & 5 mg/ml 25°C Not specified
24 Hour
Stability in solutions Glass Ringer’s lactate solution 0,25 & 5 mg/ml 4°C Protect from light
60 Day
Stability in solutions Glass Sodium chloride 0,45% 0,25 & 5 mg/ml -15°C Protect from light
30 Day
Stability in solutions Glass Sodium chloride 0,45% 0,25 & 5 mg/ml 25°C Not specified
24 Hour
Stability in solutions Glass Sodium chloride 0,45% 0,25 & 5 mg/ml 4°C Protect from light
60 Day

  Mentions Légales