Last update :
27/01/2026
References   References 5153  
Type : Journal

Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : Chayem A, Quevedo J, Cure S, Jemmely N, Demoré B, Esteban-Cartelle B, Anaya BJ, Penalver GA, Serrano DR, D'Huart Elise.
Title : Cefepime/enmetazobactam : Physicochemical stability of a novel β-Lactam/β-Lactamase Inhibitor Combination in Syringes and Elastomeric Devices.
Reference : Antibiotics ;15,114 2026

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Other methods : 
PH measurement 
Comments : 
Degradation products detected but not quantified

List of drugs
injectionCefepime enmetazobactam Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 125/31.25 mg/mL 22-25°C Light
12 Hour
Stability in solutions Polypropylen Syringe Glucose 5% 125/31.25 mg/mL 22-25°C Light
24 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 25/6.25 mg/mL 2-8°C Protect from light
24 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 25/6.25 mg/mL 32°C Protect from light
12 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 50/12.5 mg/mL 32°C Protect from light
12 Hour
Stability in solutions Polyisoprene elastomer Glucose 5% 25/6.25 mg/mL 32°C Protect from light
12 Hour
Stability in solutions Polyisoprene elastomer Glucose 5% 50/12.5 mg/mL 32°C Protect from light
12 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 25/6.25 mg/mL 32°C Protect from light
12 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 50/12.5 mg/mL 32°C Protect from light
12 Hour
Stability in solutions Silicone elastomer Glucose 5% 25/6.25 mg/mL 32°C Protect from light
24 Hour
Stability in solutions Silicone elastomer Glucose 5% 50/12.5 mg/mL 32°C Protect from light
24 Hour

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