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References   References 5105  
Type : Journal
Research teams : Créteil - Henri Mondor University Hospital, Department of Pharmacy
Authors : Vieillard V, Foulley L, Benkhalifa S, Paul M.
Title : Physicochemical stability of a bevacizumab biosimilar in vials and diluted preparations: Implications for hospital practice andinventory management.
Reference : Ann Pharm Fr 2025
Level of Evidence : 
Level of evidence A+
Physical stability : 
Turbidimetry Protein: Size Exclusion Chromatography Protein: Dynamic Light Scattering 
Chemical stability : 
Protein: ionic chromatography
Protein: ultraviolet spectrometry and second derivative
Protein: ultraviolet spectrometry
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
List of drugs
injectionBevacizumab Anticancer drug
Stability in solutions Glass None 25 mg/ml 20-25°C Protect from light
72 Hour
Biosimilar
Stability in solutions partially used vials None 25 mg/ml 2-8°C Protect from light
60 Day
Biosimilar
Stability in solutions Polyolefine Sodium chloride 0,9% 1,4 & 16,5 mg/ml 2-8°C Protect from light
24 Hour
Biosimilar
Stability in solutions Polyolefine Sodium chloride 0,9% 1,4 & 16,5 mg/ml 25°C Protect from light
72 Hour
Biosimilar
  Mentions Légales