Last update :
12/12/2025
References   References 5098  
Type : Journal
Web link : https://doi.org/10.1007/s40121-025-01174-7

Research teams : Madrid - Universidad Complutense de Madrid,Facultad de Farmacia
Authors : Esteban‑Cartelle B, Anaya B.J, Menéndez‑Conde C.P, Vicente‑Oliveros N , Serrano D.R, Álvarez‑Díaz A.
Title : Stability of Ceftobiprole Medocaril in Portable Elastomeric Infusion Devices.
Reference : Infect Dis Ther ; 14:1685–1696. 2025

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Method not shown but the article refers to a validated method
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
injectionCeftobiprole medocaril sodium Antibiotic
Factors which affect stability Solvent Glucose 5% Induces Reduced stability
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Silicone elastomer Sodium chloride 0,9% 6,25 mg/ml 2-8°C Not specified
24 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 6,25 mg/ml 25°C Not specified
12 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 6,25 mg/ml 32°C Not specified
8 Hour

  Mentions Légales