Last update :
16/07/2025
References   References 4931  
Type : Journal
Web link : https://ijpc.com/Abstracts/Abstract.cfm?ABS=5453

Research teams : Rotterdam - Fagron BV
Authors : Marianni B, Costa Vicente Silva C, Polonini H.
Title : Compatibility of Active Pharmaceutical Ingredients Combinations Compounded in Cleoderm, a Cream Base for Personalized Dermatological Treatments.
Reference : Int J Pharm Compound ;29,2:150-162 2025

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
OintmentsAdapalene Various
OintmentsAzelaique acide Various
OintmentsBenzoyl peroxyde Various
OintmentsHydrocortisone Anti-inflammatory
OintmentsHydroquinone Various
OintmentsNicotinamide Vitamin
OintmentsTretinoin Various
Stability of mixtures
plastic bottle Ethoxydiglycol 4000 mg
butylated hydroxytoluene 20 mg
Sodium metabisulfite 160 mg
Cleoderm® >> 40 g
15-30 °C Protect from light
Ointments Hydroquinone powder ® =? 1600 mg
Ointments Hydrocortisone powder ® = ? 400 mg
Ointments Tretinoin powder ® = ? 5 mg
14 Day
plastic bottle Ethoxydiglycol 1000 mg
Cleoderm® >> 40 g
15-30°C Protect from light
Ointments Adapalene powder ® = ? 40 mg
Ointments Benzoyl peroxyde powder ® = ? 400 mg
180 Day
plastic bottle Ethoxydiglycol 1000 mg
Cleoderm® >> 40 g
15-30°C Protect from light
Ointments Benzoyl peroxyde powder ® = ? 2000 mg
Ointments Adapalene powder ® = ? 120 mg
180 Day
plastic bottle propylene glycol 10 g
Cleoderm® >> 40 g
15-30°C Protect from light
Ointments Azelaique acide powder ® = ? 6 g
Ointments Nicotinamide powder ® = ? 1,6 g
180 Day
plastic bottle propylene glycol 10 g
Cleoderm® >> 40 g
15-30°C Protect from light
Ointments Azelaique acide powder ® = ? 8 g
Ointments Nicotinamide powder ® = ? 1,6 g
180 Day
plastic bottle Ethoxydiglycol 2 g
butylated hydroxytoluene 40 mg
Cleoderm® >> 40 g
15-30°C Protect from light
Ointments Nicotinamide powder ® = ? 1,6 g
Ointments Tretinoin powder ® = ? 10 mg
180 Day

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