Last update :
27/11/2025
References   References 4874  
Type : Journal
Web link : https://doi.org/10.3390/ antibiotics13100970

Research teams : Basel - University Hospital Basel, Switzerland
Authors : Rentsch K.M, Khanna N, Halbeisen D, Osthoff M.
Title : Enhancing Stability and Investigating Target Attainment of Benzylpenicillin in Outpatient Parenteral Antimicrobial Therapy: Insights from In Vitro and In Vivo Evaluations.
Reference : Antibiotics ; 13, 970. 2024

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No visual inspection
Degradation products detected but not quantified
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
injectionPenicillin G sodium Antibiotic
Stability in solutions Silicone elastomer NaCl 0.9% citrate buffer 0.3% pH7 10 MUI/ml 2-8°C Not specified
7 Day
Stability in solutions Silicone elastomer NaCl 0.9% citrate buffer 0.3% pH7 20 MUI/ml 2-8°C Not specified
7 Day
Stability in solutions Silicone elastomer NaCl 0.9% citrate buffer 0.3% pH7 40 MUI/ml 2-8°C Not specified
7 Day

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