Last update :
10/07/2024
References   References 4824  
Type : Journal

Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : Doncheva R, D'Huart E, Sobalak N, Vigneron J, Demoré B.
Title : Physicochemical stability of pevonedistat at 50, 100 and 200 µg/mL diluted in 0.9% sodium chloride and at 10 mg/mL in partially used vials.
Reference : EJHP 2024

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionPevonedistat Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 0,05 mg/mL 2-8°C Protect from light
14 Day
Stability in solutions Glass Sodium chloride 0,9% 0,2 mg/mL 2-8°C Protect from light
14 Day
Stability in solutions partially used vials None 10 mg/mL 2-8°C Protect from light
7 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 0,1 mg/mL 2-8°C Protect from light
14 Day

  Mentions Légales