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References   References 4792  
Type : Journal
Web link : 10.1136/ejhpharm-2023-003784
Research teams : Brisbane - The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia
Authors : Sime F.B, Wallis S, Jamieson C, Hills T, Gilchrist M, Santillo M, Seaton R.A, Drummond F, Roberts J.
Title : Evaluation of the stability of aciclovir in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy.
Reference : EJHP 2023
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionAciclovir sodium Antiviral
Stability in solutions Silicone elastomer Sodium chloride 0,9% 0,83 mg/ml 19°C Protect from light
14 Day
Stability in solutions Silicone elastomer Sodium chloride 0,9% 10 mg/ml 19°C Protect from light
14 Day
Stability in solutions Silicone elastomer Sodium chloride 0,9% 10 mg/ml 32°C Protect from light
24 Hour
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