Last update :
17/04/2024
References   References 4761  
Type : Journal
Web link : https://doi.org/10.1515/pthp-2022-0009

Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : D'Huart E, Sacrez M, Vigneron J, Demoré B.
Title : Physicochemical stability of Cabazitaxel Zentiva® solution in vials after opening and diluted- solutions in three infusion bags.
Reference : Pharmaceutical Technology in Hospital Pharmacy ; 8(1): 20220009 2023

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionCabazitaxel Anticancer drug
Stability in solutions Partially used vials None 20 mg/ml 25°C Protect from light
28 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,1 >>0,26 mg/ml 25°C Protect from light
28 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,1 >>0,26 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,1 >>0,26 mg/ml 25°C Protect from light
28 Day

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