Last update :
08/12/2024
References   References 4755  
Type : Journal
Web link : https://journals.sagepub.com/doi/10.1177/10781552231170583

Research teams : Créteil - Henri Mondor University Hospital, Department of Pharmacy
Authors : Vieillard V, Le Guyader G, Jallades A, Astier A.
Title : Extended physicochemical stability of cetuximab in opened vials and infusion bags when stored at 4°C and 25°C.
Reference : J Oncol Pharm Practice 2023

Level of Evidence : 
Level of evidence A+
Physical stability : 
Turbidimetry Protein: Size Exclusion Chromatography Protein: Dynamic Light Scattering 
Chemical stability : 
Protein: ionic chromatography
Protein: ultraviolet spectrometry and second derivative
ultraviolet spectrometry
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
injectionCetuximab Anticancer drug
Stability in solutions partially used vials None 5 mg/ml 25°C Not specified
3 Day
Stability in solutions Polypropylene None 5 mg/ml 25°C Not specified
3 Day
Stability in solutions Polypropylene None 5 mg/ml 4°C Not specified
90 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 1 mg/ml 25°C Not specified
3 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 1 mg/ml 4°C Not specified
90 Day

  Mentions Légales