Last update :
21/02/2024
References   References 4750  
Type : Journal
Web link : https://doi.org/ 10.3390/pharmaceutics15030755

Research teams : Clermont-Ferrand - University Hospital Gabriel Monpied, Department of Pharmacy
Authors : Lebrat M, Bouattour Y, Gaudet C, Yessaad M, Jouannet M, Wasiak M, Dhifallah I, Beyssac E, Garrait G, Chennell P, Sautou V.
Title : Development and Stability of a New Formulation of Pentobarbital Suppositories for Paediatric Procedural Sedation.
Reference : Pharmaceutics ,15, 755. 2023

Level of Evidence : 
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Comments : 

List of drugs
SuppositoryPentobarbital General anesthetic
Stability in solutions Not specified Powder 30 mg
® = ?
Witepsol® W25 1,07 g
2-8°C Protect from light
288 Day
Stability in solutions Not specified Powder 40 mg
® = ?
Witepsol® W25 1,06 g
2-8°C Protect from light
288 Day
Stability in solutions Not specified Powder 50 mg
® = ?
Witepsol® W25 1,05 g
2-8°C Protect from light
288 Day
Stability in solutions Not specified Powder 60 mg
® = ?
Witepsol® W25 1,04 g
2-8°C Protect from light
288 Day
Stability in solutions Not specified Powder 30 mg
® = ?
Witepsol® W25 0,861 g
Oleic acid 0,223 g
2-8°C Protect from light
196 Day
Stability in solutions Not specified Powder 40 mg
® = ?
Witepsol® W25 0,830 g
Oleic acid 0,253 g
2-8°C Protect from light
196 Day
Stability in solutions Not specified Powder 50 mg
® = ?
Witepsol® W25 0,801 g
Oleic acid 0,280 g
2-8°C Protect from light
196 Day
Stability in solutions Not specified Powder 60 mg
® = ?
Witepsol® W25 0,775 g
Oleic acid 0,304 g
2-8°C Protect from light
196 Day

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