Last update :
23/11/2022
References   References 4702  
Type : Journal
Web link : https://journals.lww.com/ejop/Fulltext/2022/06000/Physicochemical_stability_of_pemetrexed_diarginine.1.aspx

Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : Nisse Y-E, Sobalak N, Vigneron J, Demoré B.
Title : Physicochemical stability of pemetrexed diarginine at 25 mg/mL in partially-used vials and at 3 and 12 mg/mL diluted in dextrose 5% or in sodium chloride 0.9% in polyolefin bags.
Reference : EJOP ; 5: 2. 2022

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionPemetrexed diarginine Anticancer drug
Stability in solutions Glass None 25 mg/ml 2-8°C With or without light
7 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 3 & 12 mg/ml 2-8°C With or without light
28 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 3 & 12 mg/ml 20-25°C With or without light
7 Day

  Mentions Légales