Last update :
16/07/2021
References   References 4546  
Type : Journal
Web link : http://dx.doi.org/10.1136/ejhpharm-2020-002620

Research teams : Paris - Clinical Pharmacy Department, University Hospital Necker-Enfants Malades
Authors : Vidal F, Cotteret C, Negbane A, Sebti M, Hinterlang M, Cisternino S, Schlatter J.
Title : Stability of pemetrexed diarginine concentrates for solution in vials and diluted in 0.9% sodium chloride and dextrose 5% polyolefin infusion bags.
Reference : EJHP 2021

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Degradation products detected but not quantified

List of drugs
InjectionPemetrexed diarginine Anticancer drug
Stability in solutions Glass None 25 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Glass None 25 mg/ml 22-25°C Light
1 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 12 mg/ml 2-8°C Protect from light
4 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 12 mg/ml 22-25°C Light
1 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 4,9 mg/ml 2-8°C Protect from light
4 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 4,9 mg/ml 22-25°C Light
1 Day

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