Last update :
30/09/2020
References   References 4455  
Type : Journal
Web link : 10.1177/1078155220937405

Research teams : Tunis - Centre National de Greffe de Moelle Osseuse
Authors : Ben Ayed W, Drira C, Ali Soussi M, Ouesleti H, Hamdene B, Khrouf M, Safta F, Fradi I.
Title : Physical and chemical stability of cytarabine in polypropylene syringes.
Reference : J Oncol Pharm Practice online first 2020

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
InjectionCytarabine Anticancer drug
Factors which affect stability Temperature 25°C Induces Reduced stability
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 25°C Protect from light
14 Day
Stability in solutions Glass Sodium chloride 0,9% 10 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Glass Sodium chloride 0,9% 10 mg/ml 25°C Protect from light
5 Day
Stability in solutions Glass Sodium chloride 0,9% 5 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Glass Sodium chloride 0,9% 5 mg/ml 25°C Protect from light
8 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 25°C Protect from light
14 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 10 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 10 mg/ml 25°C Protect from light
5 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 5 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 5 mg/ml 25°C Protect from light
8 Day

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