Last update :
03/05/2024
References   References 442  
Type : Journal

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Jarosinski PF, Kennedy PE, Gallelli JF.
Title : Stability of a concentrated trimethoprim-sulfamethoxazole admixtures.
Reference : Am J Hosp Pharm ; 46: 732-737. 1989

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Increased concentration unexplained

List of drugs
InjectionCo-trimoxazole Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,64 / 3,2 mg/ml 23°C-25°C Not specified
48 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 1,6 / 8 mg/ml 23°C-25°C Not specified
1 Hour
Stability in solutions Glass Sodium chloride 0,9% 0,8 / 4 mg/ml 23°C-25°C Not specified
14 Hour
Stability in solutions Glass Sodium chloride 0,9% 1,07 / 5,33 mg/ml 23°C-25°C Not specified
2 Hour
Stability in solutions Glass Glucose 5% 0,8 / 4 mg/ml 23°C-25°C Not specified
24 Hour
Stability in solutions Glass Glucose 5% 1,07 / 5,33 mg/ml 23°C-25°C Not specified
4 Hour

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