Last update :
06/08/2020
References   References 4416  
Type : Journal
Web link : https://doi.org/10.5863/1551-6776-20.3.197

Research teams : Bondy - University Hospital Jean Verdier, Department of Pharmacy
Authors : Chappe J, Osman N, Cisternino S, Fontan J-E, Schlatter J.
Title : Stability of Hydrocortisone Preservative-Free Oral Solutions.
Reference : J Pediatr Pharmacol Ther ; 20, 3: 197-202. 2015

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
Oral solutionHydrocortisone sodium succinate Anti-inflammatory
Stability in solutions Glass Medicine bottle for injection 100 mg
Hydrocortisone Upjohn®
Citric acid 200 mg
Purified water >> 100 mL
NaOH 1N >> pH 5,5
3-7°C Protect from light
21 Day
Stability in solutions Glass Medicine bottle for injection 100 mg
Hydrocortisone Upjohn®
Citric acid 200 mg
Purified water >> 100 mL
NaOH 1N >> pH 6,5
3-7°C Protect from light
21 Day
Stability in solutions Glass Medicine bottle for injection 100 mg
Hydrocortisone Upjohn®
Water for injection >> 100 mL
Hydrochloric acid 1N >> pH 4
3-7°C Protect from light
14 Day

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