Last update :
10/07/2024
References   References 4405  
Type : Journal
Web link : 10.1691/ph.2020.9155

Research teams : Valence - Institute for Health Research (INCLIVA), Pharmacy Service, University Clinical Hospital of Valencia
Authors : Ezquer-Garin C, Ferriols-Lisart R, Martinez-López LM, Sangrador-Pelluz C, Nicolás-Picó J, Alós-Almiñana M.
Title : Stability of tedizolid phosphate-sodium rifampicin and tedizolid phosphate-meropenem admixtures in intravenous infusion bags stored at different temperatures
Reference : Pharmazie ; 75: 172-176. 2020

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 

List of drugs
injectionMeropenem Antibiotic
Compatible 4 mg/ml + injectionTedizolid phosphate 0.8 mg/ml + Sodium chloride 0,9%
injectionRifampicin Antibiotic
Compatible 2.4 mg/ml + injectionTedizolid phosphate 0.8 mg/ml + Sodium chloride 0,9%
injectionTedizolid phosphate Antibiotic
Compatible 0.8 mg/ml + injectionMeropenem 4 mg/ml + Sodium chloride 0,9%
Compatible 0.8 mg/ml + injectionRifampicin 2.4 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Sodium chloride 0,9% -25 >> -15°C Protect from light
injection Tedizolid phosphate 0.8 mg/ml
injection Meropenem 4 mg/ml
8 Day
Polypropylene Sodium chloride 0,9% -25 >> -15°C° Protect from light
injection Rifampicin 2.4 mg/ml
injection Tedizolid phosphate 0.8 mg/ml
28 Day
Polypropylene Sodium chloride 0,9% 2-8°C Protect from light
injection Tedizolid phosphate 0.8 mg/ml
injection Meropenem 4 mg/ml
6 Day
Polypropylene Sodium chloride 0,9% 2-8°C Protect from light
injection Tedizolid phosphate 0.8 mg/ml
injection Rifampicin 2.4 mg/ml
6 Day
Polypropylene Sodium chloride 0,9% 23-27°C Protect from light
injection Rifampicin 2.4 mg/ml
injection Tedizolid phosphate 0.8 mg/ml
7 Hour
Polypropylene Sodium chloride 0,9% 25°C Protect from light
injection Tedizolid phosphate 0.8 mg/ml
injection Meropenem 4 mg/ml
12 Hour

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