Last update :
18/04/2024
References   References 4403  
Type : Journal
Web link : https://doi.org/10.1016/j.jpba.2019.112973

Research teams : Porto Alegre - Pharmacy School of Federal University of Rio Grande do Sul
Authors : De Souza Barbosa F, Capra Pezzi L, Tsao M, Manoela Dias Macedo S, Franco de Oliveira T, Schapoval EES, Mendez ASL.
Title : Stability in clinical use and stress testing of meropenem antibiotic by direct infusion ESI-Q-TOF: Quantitative method and identification of degradation products.
Reference : J Pharm Biomed Anal ; 179: 112973. 2020

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Degradation products detected but not quantified

List of drugs
InjectionMeropenem Antibiotic
Factors which affect stability Solvent Glucose 5% Induces Reduced stability
Stability in solutions Glass Water for Injection 50 mg/ml 23-27°C Not specified
7 Hour
Stability in solutions Not specified Sodium chloride 0,9% 5 mg/ml 23-27°C Not specified
12 Hour
Stability in solutions Not specified Sodium chloride 0,9% 5 mg/ml 4°C Not specified
24 Hour
Stability in solutions Not specified Glucose 5% 5 mg/ml 23-27°C Not specified
4 Hour

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