Last update :
13/08/2020
References   References 4378  
Type : Journal

Research teams : Hobart - University of Tasmania, School of Pharmacy
Authors : Harmanjeet H, Jani H, Zaidi S.T.R, Wanandy T, Castelino R.L, Sud K, Peterson G.M, Patel R.P.
Title : Stability of ceftolozane and tazobactam in different peritoneal dialysis solutions.
Reference : Perit Dial Int 2020

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionCeftolozane / tazobactam Antibiotic
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0.02/0.01 mg/ml 37°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0.02/0.01 mg/ml 4°C Not specified
168 Hour
Stability in solutions Polyvinyl chloride Physionéal® 1.36 (Baxter) 0.055/0.027 mg/ml 37°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride Physionéal® 1.36 (Baxter) 0.055/0.027 mg/ml 4°C Not specified
168 Hour
Stability in solutions Polyvinyl chloride Physionéal® 2.27 (Baxter) 0.055/0.027 mg/ml 37°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride Physionéal® 2.27 (Baxter) 0.055/0.027 mg/ml 4°C Not specified
168 Hour
Stability in solutions Polyvinyl chloride Physionéal® 3.86 (Baxter) 0.055/0.027 mg/ml 37°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride Physionéal® 3.86 (Baxter) 0.055/0.027 mg/ml 4°C Not specified
168 Hour
Stability in solutions Polyvinyl chloride Dianéal® 1.5% glucose (Baxter) 0.02/0.01 mg/ml 37°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride Dianéal® 1.5% glucose (Baxter) 0.02/0.01 mg/ml 4°C Not specified
168 Hour
Stability in solutions Polyvinyl chloride Dianéal® 2.5% glucose (Baxter) 0.02/0.01 mg/ml 37°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride Dianéal® 2.5% glucose (Baxter) 0.02/0.01 mg/ml 4°C Not specified
168 Hour
Stability in solutions Polyvinyl chloride Dianéal® 4.25% glucose (Baxter) 0.02/0.01 mg/ml 37°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride Dianéal® 4.25% glucose (Baxter) 0.02/0.01 mg/ml 4°C Not specified
168 Hour
Stability in solutions Polyvinyl chloride Balance® 1.3% Frésénius 0.04/0.02 mg/ml 37°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride Balance® 1.3% Frésénius 0.04/0.02 mg/ml 4°C Not specified
168 Hour
Stability in solutions Polyvinyl chloride Balance® 2.5% Frésénius 0.04/0.02 mg/ml 37°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride Balance® 2.5% Frésénius 0.04/0.02 mg/ml 4°C Not specified
168 Hour

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