Last update :
11/08/2022
References   References 435  
Type : Journal

Research teams : Charleston - Medical University of South Carolina
Authors : Wiest DB, Maish WA, Garner SS, El-Chaar GM.
Title : Stability of amphotericin B in four concentrations of dextrose injection.
Reference : Am J Hosp Pharm ; 48: 2430-2433. 1991

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products not observed in real conditions

List of drugs
InjectionAmphotericin B Antifungal
Stability in solutions Polyvinyl chloride Glucose 5% 0,1 mg/ml 15°C-25°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Glucose 10% 0,1 mg/ml 15°C-25°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Glucose 15% 0,1 mg/ml 15°C-25°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Glucose 20% 0,1 mg/ml 15°C-25°C Protect from light
24 Hour

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