Last update :
31/05/2020
References   References 4348  
Type : Journal

Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : D'Huart E, Vigneron J, Charmillon A, Clarot I, Demor? B.
Title : Physicochemical Stability of Vancomycin at High Concentrations in Polypropylene Syringes.
Reference : Can J Hosp Pharm ;72(5):360-8 2019

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionVancomycin hydrochloride Antibiotic
Factors which affect stability Concentration Sodium chloride 0,9%[>62,5 mg/ml] Induces Precipitation
Stability in solutions Polypropylen Syringe Glucose 5% 62,5 mg/ml 20-25°C Light
48 Hour
Stability in solutions Polypropylen Syringe Glucose 5% 83,3 mg/ml 20-25°C Light
48 Hour

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