Last update :
15/10/2021
References   References 4314  
Type : Journal

Research teams : Corvalis - Oregon State University, College of Pharmacy
Authors : DenHerder J.M, Reed R.L, Sargent J.L, Bobe G, Stevens J.F, Helen E Diggs H.E.
Title : Effects of Time and Storage Conditions on the Chemical and Microbiologic Stability of Diluted Buprenorphine for Injection.
Reference : J Am Pharm Assoc ; 56, 4: 457-461. 2017

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 

List of drugs
InjectionBuprenorphine hydrochloride Analgesic
Factors which affect stability Container Polypropylen Syringe Induces Reduced stability
Stability in solutions Glass NaCl 0,9% + antibacterial 0,03 mg/ml 1-9°C Protect from light
180 Day
Stability in solutions Glass NaCl 0,9% + antibacterial 0,03 mg/ml 18-24°C Protect from light
180 Day

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