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References   References 4211  
Type : Journal
Web link : https://doi.org/10.1371/journal.pone.0221391
Research teams : Poitiers - Centre Hospitalier Universitaire de Poitiers
Authors : Binson G, Grignon C, Le Moal G, Lazaro P, Lelong J, Roblot F, Venisse N, Dupuis A.
Title : Overcoming stability challenges during continuous intravenous administration of high-dose amoxicillin using portable elastomeric pumps.
Reference : PlosOne 2019
Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Degradation products detected but not quantified
No visual inspection
List of drugs
InjectionAmoxicillin sodium Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Factors which affect stability Concentration Increase Induces Reduced stability
Stability in solutions Silicone elastomer Sodium chloride 0,45% 25 mg/ml 25°C Not specified
12 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,45% 25 mg/ml 4-8°C Not specified
24 Hour
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