Last update :
28/04/2024
References   References 4201  
Type : Journal
Web link : https://doi.org/10.1093/ajhp/zxaa040

Research teams : Lille - Faculté des Sciences Pharmaceutiques et Biologiques
Authors : Gilliot S, Masse M, Feutry F, Barthélémy C, Décaudin B, Genay S, Odou P.
Title : Long-term stability of ready-to-use 1-mg/mL midazolam solution.
Reference : Am J Health-Syst Pharm ; 77, 9: 681-689. 2020

Level of Evidence : 
Level of evidence A+
Physical stability : 
Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionMidazolam hydrochloride Anxiolytic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml -20°C Not specified
365 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 2-8°C Not specified
365 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 23-25°C Not specified
90 Day
Stability in solutions AT-Closed vial® Sodium chloride 0,9% 1 mg/ml -20°C Not specified
365 Day
Stability in solutions AT-Closed vial® Sodium chloride 0,9% 1 mg/ml 2-8°C Not specified
365 Day
Stability in solutions AT-Closed vial® Sodium chloride 0,9% 1 mg/ml 23-25°C Not specified
90 Day

  Mentions Légales