Last update :
03/05/2024
References   References 4141  
Type : Journal
Web link : https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpt.12674

Research teams : Hobart - University of Tasmania, School of Pharmacy
Authors : Al Madfai F, Valah B, Zaidi S.T.R, Wanandy T, Ming M.C, Peterson G.M, Patel R.P.
Title : Stability of dobutamine in continuous ambulatory delivery devices.
Reference : J Clin Pharm Ther : 530-535. 2018

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionDobutamine hydrochloride Cardiotonic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 35°C Not specified
12 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Not specified
7 Day

  Mentions Légales