Last update :
15/10/2021
References   References 4074  
Type : Journal
Web link : https://ejhp.bmj.com/content/25/2/107

Research teams : Madrid - Universidad Complutense de Madrid,Facultad de Farmacia
Authors : Ferrandez J, Sanchez R, Diaz D, Diaz M, Estevan M, Garcia T.
Title : Stability of daptomycin reconstituted vials and infusion solutions.
Reference : EJHP ; 25: 107-110. 2018

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Water loss by evaporation 
Comments : 
Degradation products not observed in real conditions
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
InjectionDaptomycin Antibiotic
Stability in solutions Glass Sodium chloride 0,9% 50 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass Sodium chloride 0,9% 50 mg/ml 25°C Protect from light
2 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 14 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 14 mg/ml 25°C Protect from light
4 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 5,6 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 5,6 mg/ml 25°C Protect from light
2 Day

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