Last update :
18/04/2024
References   References 4051  
Type : Journal

Research teams : Angers - Institut de cancérologie de l’ouest - Paul Papin, Pharmacy Department
Authors : Robert J, Sorrieul J, Kieffer H, Folliard C, Gibory V, Dupoiron D, Devys C.
Title : Stability study of morphine and baclofen solution in polypropylene syringes.
Reference : Pharmaceutical Technology in Hospital Pharmacy ;2,4:173-180 2017

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionBaclofen Various
Compatible 0.08 & 1.6 mg/ml + InjectionMorphine sulfate 1 & 10 mg/ml + Sodium chloride 0,9%
InjectionMorphine hydrochloride Analgesic
InjectionMorphine sulfate Analgesic
Compatible 1 & 10 mg/ml + InjectionBaclofen 0.08 & 1.6 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Sodium chloride 0,9% 2-8°C Protect from light
Injection Morphine hydrochloride 1 mg/ml
Injection Baclofen 0.08 mg/ml
7 Day
Polypropylene Sodium chloride 0,9% 2-8°C Protect from light
Injection Baclofen 1.6 mg/ml
Injection Morphine hydrochloride 10 mg/ml
7 Day
Polypropylene Sodium chloride 0,9% 23-27°C Protect from light
Injection Baclofen 1.6 mg/ml
Injection Morphine hydrochloride 10 mg/ml
7 Day
Polypropylene Sodium chloride 0,9% 23-27°C Protect from light
Injection Morphine hydrochloride 1 mg/ml
Injection Baclofen 0.08 mg/ml
7 Day

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