Last update :
03/05/2024
References   References 4047  
Type : Journal

Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Kim S.H, Krämer I.
Title : Physicochemical stability of carfilzomib (Kyprolis®) containing solutions in glass vials, ready-to-administer plastic syringes and infusion bags over a 28-day storage period.
Reference : J Oncol Pharm Practice ;25,2: 339-350 2017

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionCarfilzomib Anticancer drug
Stability in solutions Glass Water for Injection 2 mg/ml 2-8°C Not specified
28 Day
Stability in solutions Polypropylene Water for Injection 2 mg/ml 25°C Not specified
14 Day
Stability in solutions Polypropylene Glucose 5% 0.8 mg/ml 2-8°C Not specified
28 Day
Stability in solutions Polypropylene Glucose 5% 0.8 mg/ml 25°C Not specified
10 Day
Stability in solutions Polyolefine Glucose 5% 0.6 mg/ml 2-8°C Not specified
28 Day
Stability in solutions Polyolefine Glucose 5% 0.6 mg/ml 25°C Not specified
10 Day

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