Last update :
20/01/2021
References   References 3888  
Type : Journal
Web link : http://www.pdiconnect.com/content/36/4/421.abstract

Research teams : Brisbane - Royal Brisbane and Women\'s Hospital
Authors : Ranganathan D, Naicker S,. Wallis S.C, Lipman J, . Ratanjee S.K, Roberts J.A
Title : Stability of Antibiotics for Intraperitoneal Administration in Extraneal 7.5% Icodextrin Peritoneal Dialysis Bags (STAB Study).
Reference : Perit Dial Int ; 36:421-426. 2016

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products

List of drugs
InjectionCefazolin sodium Antibiotic
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0,5 mg/ml 25°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0,5 mg/ml 37°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0,5 mg/ml 4°C Protect from light
14 Day
InjectionCeftazidime Antibiotic
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0,5 mg/ml 25°C Protect from light
2 Day
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0,5 mg/ml 37°C Protect from light
6 Hour
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0,5 mg/ml 4°C Protect from light
14 Day
InjectionGentamicin sulfate Antibiotic
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0,02 mg/ml 25°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0,02 mg/ml 37°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 0,02 mg/ml 4°C Protect from light
14 Day
InjectionVancomycin hydrochloride Antibiotic
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 1 mg/ml 25°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 1 mg/ml 37°C Protect from light
4 Day
Stability in solutions Polyvinyl chloride Extraneal® (Baxter) 1 mg/ml 4°C Protect from light
14 Day
Stability of mixtures
Polyvinyl chloride Extraneal® (Baxter) 25°C Protect from light
Injection Cefazolin sodium 0,5 mg/ml
Injection Ceftazidime 0,5 mg/ml
2 Day
Polyvinyl chloride Extraneal® (Baxter) 25°C Protect from light
Injection Cefazolin sodium 0,5 mg/ml
Injection Gentamicin sulfate 0,02 mg/ml
4 Day
Polyvinyl chloride Extraneal® (Baxter) 25°C Protect from light
Injection Gentamicin sulfate 0,02 mg/ml
Injection Vancomycin hydrochloride 1 mg/ml
14 Day
Polyvinyl chloride Extraneal® (Baxter) 37°C Protect from light
Injection Gentamicin sulfate 0,02 mg/ml
Injection Vancomycin hydrochloride 1 mg/ml
4 Day
Polyvinyl chloride Extraneal® (Baxter) 37°C Protect from light
Injection Cefazolin sodium 0,5 mg/ml
Injection Ceftazidime 0,5 mg/ml
24 Hour
Polyvinyl chloride Extraneal® (Baxter) 37°C Protect from light
Injection Cefazolin sodium 0,5 mg/ml
Injection Gentamicin sulfate 0,02 mg/ml
24 Hour
Polyvinyl chloride Extraneal® (Baxter) 4°C Protect from light
Injection Cefazolin sodium 0,5 mg/ml
Injection Ceftazidime 0,5 mg/ml
14 Day
Polyvinyl chloride Extraneal® (Baxter) 4°C Protect from light
Injection Cefazolin sodium 0,5 mg/ml
Injection Gentamicin sulfate 0,02 mg/ml
14 Day

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