Last update :
03/05/2024
References   References 3830  
Type : Journal
Web link : http://opp.sagepub.com/content/22/1/31.abstract

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Myers A.Ls, Zhang Y-P, Kawedia L, Trinh V.A, Tran H, Smith J.A, Kramer M.A.
Title : Stability study of carboplatin infusion solutions in 0.9% sodium chloride in polyvinyl chloride bags.
Reference : J Oncol Pharm Practice ; 22: 31-36. 2016

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Degradation products detected but not quantified

List of drugs
InjectionCarboplatin Anticancer drug
Factors which affect stability Temperature Increase Induces Reduced stability
Factors which affect stability Concentration Reduced concentration Induces Reduced stability
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,25 mg/ml 2-8°C Light
3 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,25 mg/ml 25°C Light
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml 2-8°C Light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml 25°C Light
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 4 mg/ml 2-8°C Light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 4 mg/ml 25°C Light
2 Day

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