Last update :
18/04/2024
References   References 3712  
Type : Journal

Research teams : Milwaukee - Medical College of Wisconsin, Department of Surgery
Authors : Ghanayem N.S, Lee L, Nelson T, Wong S, Gordon G.B, Markdante K et al.
Title : Stability of dopamine and epinephrine solutions up to 84 hours.
Reference : Pediatr Crit Care Med ; 2, 4: 315-317. 2001

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Unencrypted results (eg graphic)
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products
No visual inspection
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
InjectionDopamine hydrochloride Cardiotonic
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 10 mg/ml 23°C Not specified
84 Hour
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 2 mg/ml 23°C Not specified
84 Hour
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 30 mg/ml 23°C Not specified
84 Hour
Stability in solutions Polypropylen Syringe Glucose 10% 10 mg/ml 23°C Not specified
84 Hour
Stability in solutions Polypropylen Syringe Glucose 10% 2 mg/ml 23°C Not specified
84 Hour
Stability in solutions Polypropylen Syringe Glucose 10% 30 mg/ml 23°C Not specified
84 Hour
InjectionEpinephrine hydrochloride Sympathomimetic
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 20 µg/ml 23°C Not specified
84 Hour
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 300 µg/ml 23°C Not specified
84 Hour
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 900 µg/ml 23°C Not specified
84 Hour
Stability in solutions Polypropylen Syringe Glucose 10% 20 µg/ml 23°C Not specified
84 Hour
Stability in solutions Polypropylen Syringe Glucose 10% 300 µg/ml 23°C Not specified
84 Hour
Stability in solutions Polypropylen Syringe Glucose 10% 900 µg/ml 23°C Not specified
84 Hour

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