Last update :
12/06/2024
References   References 366  
Type : Journal

Research teams : Rensselaer - Sterling-Winthrop Research Institute
Authors : Wilson TD, Forde MD, Crain AVR, Dombrowski LJ, Joyce MA.
Title : Stability of milrinone in 0.45% sodium chloride, 0.9% sodium chloride, or 5% dextrose injections.
Reference : Am J Hosp Pharm ; 43: 2218-2220. 1986

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Thin Layer Chromatography
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionMilrinone lactate Cardiotonic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,2 mg/ml 25°C With or without light
72 Hour
Stability in solutions Glass Sodium chloride 0,45% 0,2 mg/ml 25°C With or without light
72 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,2 mg/ml 25°C With or without light
72 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,45% 0,2 mg/ml 25°C With or without light
72 Hour

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