Last update :
28/04/2024
References   References 363  
Type : Journal

Research teams : Waukegan - Du pont Critical Care, Pharmaceutical Development Department
Authors : Karnatz NN, Wong J, Baaske DM, Johnson JH, Speicher ER, Herbranson DE.
Title : Stability of esmolol hydrochloride and sodium nitroprussiate in intravenous admixtures.
Reference : Am J Hosp Pharm ; 46: 101-104. 1989

Level of Evidence : 
Level of evidence A+
Physical stability : 
Turbidimetry Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + InjectionNitroprusside sodium 0,2 mg/ml + Glucose 5%
InjectionNitroprusside sodium Vasodilator
Compatible 0,2 mg/ml + InjectionEsmolol hydrochloride 10 mg/ml + Glucose 5%
Stability of mixtures
Not specified Glucose 5% 15-30°C Protect from light
Injection Esmolol hydrochloride 10 mg/ml
Injection Nitroprusside sodium 0,2 mg/ml
24 Hour

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