Last update :
03/05/2024
References   References 3572  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=3778

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Hecq J-D, Godet M, Gillet P, Jamart J, Galanti L.
Title : Long-term Stability of Morphine Hydrochloride in 0.9% NaCl Infusion Polyolefin Bags After Freeze-thaw Treatment and in Polypropylene Syringes at 5°C ± 3°C.
Reference : Int J Pharm Compound ; 18, 1 : 78-82. 2014

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination Turbidimetry Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products
Increased concentration unexplained

List of drugs
InjectionMorphine hydrochloride Analgesic
Stability in solutions Polyolefine Sodium chloride 0,9% 1 mg/ml -20°C Protect from light
90 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 1 mg/ml 2-8°C Not specified
58 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 2-8°C Not specified
58 Day

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