Last update :
15/04/2024
References   References 3433  
Type : Journal
Web link : http://www.ajhp.org/content/70/15/1336.abstract

Research teams : Aurora - Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado
Authors : Preslaski C.R, Mueller S.W, Wempe M.F, Robert MacLaren R.
Title : Stability of dexmedetomidine in polyvinyl chloride bags containing 0.9% sodium chloride injection.
Reference : Am J Health-Syst Pharm ; 70:1336-1341 2013

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionDexmedetomidine Sympathomimetic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 4 >> 20 µg/ml 21-25°C Not specified
48 Hour

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