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References   References 3297  
Type : Journal
Research teams : Grenade - Faculty of Science, Department of Analytical Chemistry
Authors : Salmeron-Garcia A, Lopez-Lopez E, Roma E, Cabeza J, Navas N, Capitan-Vallvey L.F.
Title : Development of an LC–DAD Method for Analysis of Dexketoprofen, Tramadol, and Haloperidol. Study of the Stability of Mixtures Used for Patient-Controlled Analgesia.
Reference : Chromatographia ; 68, 9-10: 767-772. 2008
Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
List of drugs
InjectionDexketoprofen Anti-inflammatory
InjectionHaloperidol lactate Neuroleptic
InjectionTramadol hydrochloride Analgesic
Stability of mixtures
Polyolefine NaCl 0,9% or Glucose 5% - 20°C Protect from light
Injection Dexketoprofen 2,5 mg/ml
Injection Tramadol hydrochloride 5 mg/ml
Injection Haloperidol lactate 0,05 mg/ml
30 Day
Polyolefine NaCl 0,9% or Glucose 5% 25°C With or without light
Injection Dexketoprofen 2,5 mg/ml
Injection Tramadol hydrochloride 5 mg/ml
Injection Haloperidol lactate 0,05 mg/ml
30 Day
Polyolefine NaCl 0,9% or Glucose 5% 4°C Protect from light
Injection Dexketoprofen 2,5 mg/ml
Injection Tramadol hydrochloride 5 mg/ml
Injection Haloperidol lactate 0,05 mg/ml
30 Day
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