Last update :
17/09/2021
References   References 3218  
Type : Journal

Research teams : Caen - University Hospital, Clinical Research department
Authors : Peyro Saint Paul L, Albessard F, Gaillard C, Debruyn D, Ryckelynck J Ph, Antoine Coquerel, Lobbedez T
Title : Daptomycin Compatibility in Peritoneal Dialysis Solutions
Reference : Perit Dial Int ; 31: 492?495. 2011

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Increased concentration unexplained
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products not observed in real conditions

List of drugs
InjectionDaptomycin Antibiotic
Stability in solutions Glass Physionéal® 1.36 (Baxter) 100 mg/ml 25°C Protect from light
6 Hour
Stability in solutions Glass Physionéal® 1.36 (Baxter) 100 mg/ml 37°C Protect from light
6 Hour
Stability in solutions Glass Physionéal® 1.36 (Baxter) 100 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Nutrineal® 50 & 200 mg/ml 37°C Protect from light
6 Hour
Stability in solutions Polyvinyl chloride Nutrineal® 50 & 200 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Physionéal® 1.36 (Baxter) 50 & 200 mg/ml 25°C Protect from light
6 Hour
Stability in solutions Polyvinyl chloride Physionéal® 1.36 (Baxter) 50 & 200 mg/ml 37°C Protect from light
6 Hour
Stability in solutions Polyvinyl chloride Physionéal® 1.36 (Baxter) 50 & 200 mg/ml 4°C Protect from light
24 Hour

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