Last update :
22/01/2021
References   References 3183  
Type : Journal
Web link : http://www.esop.li/ejop.php

Research teams : Plymouth - Derriford Hospital,Department of Pharmacy
Authors : Sewell G
Title : Physical and chemical stability of cisplatin infusions in PVC containers.
Reference : EJOP ; 4, 3: 11-13. 2010

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement Mass balance 
Comments : 
No comments for the degradation products
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
InjectionCisplatin Anticancer drug
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,1 mg/ml 25°C Protect from light
28 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,4 mg/ml 25°C Protect from light
28 Day
InjectionMagnesium sulfate Electrolyte
InjectionPotassium chloride Electrolyte
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 25°C Protect from light
Injection Cisplatin 0,1 mg/ml
Injection Potassium chloride 2,9 mEq/l
Injection Magnesium sulfate 1,9 mg/ml
28 Day

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