Last update :
18/04/2024
References   References 3145  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/67/18/1539

Research teams : Hartford - Center for Anti-Infective Research and Development
Authors : Crandon JL, Sutherland C, Nicolau DP.
Title : Stability of doripenem in polyvinyl chloride bags and elastomeric pumps.
Reference : Am J Health-Syst Pharm ; 67: 1539-1544. 2010

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
No comments for the degradation products
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
InjectionDoripenem Antibiotic
Factors which affect stability Concentration Increase Induces Reduced stability
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Not specified
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 5 mg/ml 4°C Not specified
10 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 5 et 10 mg/ml -20°C Protect from light
28 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 5 et 10 mg/ml 25°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 5 et 10 mg/ml 25°C Not specified
16 Hour
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Not specified
10 Day
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 5 mg/ml 4°C Not specified
10 Day
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 5 et 10 mg/ml 25°C Not specified
24 Hour
Stability in solutions Polyisoprene elastomer Glucose 5% 5 et 10 mg/ml 25°C Not specified
16 Hour

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