Last update :
18/04/2024
References   References 2791  
Type : Journal
Web link : https://doi.org/10.1016/j.ijpharm.2014.12.025

Research teams : Utrecht - Faculty of pharmacy, State university of Utrecht
Authors : Mehta A.M,.Van den Hoven J.M, Rosing H,.Hillebrand M.J.X, Nuijen B,. Huitema A.D.R, Beijnen J.H,.Verwaal V.J.
Title : Stability of oxaliplatin in chloride-containing carrier solutions used in hyperthermic intraperitoneal chemotherapy.
Reference : Int J Pharm ; 479 : 23-27. 2015

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No visual inspection
Degradation products identified and quantified

List of drugs
InjectionOxaliplatin Anticancer drug
Stability in solutions Glass Glucose 5% 0,1 mg/ml 42°C Not specified
2 Hour
Stability in solutions Glass Ringer’s lactate solution 0,1 mg/ml 42°C Not specified
0.5 Hour
Stability in solutions Glass  Dianéal® PD4 1.36% glucose (Baxter) 0,1 mg/ml 42°C Not specified
0.5 Hour

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