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References   References 26  
Type : Journal
Research teams : Athens - University of Georgia, College of Pharmacy
Authors : Stewart JT, Warren FW, King DT, Venkateshwaran TG, Ponder GW, Fox JL.
Title : Stability of ondansetron hydrochloride, doxorubicin hydrochloride, and dacarbazine or vincristine sulfate in elastomeric portable infusion devices and polyvinyl chloride bags.
Reference : Am J Health-Syst Pharm ; 54: 915-920. 1997
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No comments for the degradation products
Method not shown but the article refers to a validated method
List of drugs
InjectionDacarbazine Anticancer drug
InjectionDoxorubicin hydrochloride Anticancer drug
InjectionOndansetron hydrochloride Antiemetic
InjectionVincristine sulfate Anticancer drug
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 30°C Not specified
Injection Ondansetron hydrochloride 0,96 mg/ml
Injection Doxorubicin hydrochloride 0,8 mg/ml
Injection Vincristine sulfate 0,028 mg/ml
5 Day
Polyvinyl chloride Glucose 5% 30°C Not specified
Injection Ondansetron hydrochloride 0,64 mg/ml
Injection Dacarbazine 8 mg/ml
Injection Doxorubicin hydrochloride 0,8 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 4°C Protect from light
Injection Ondansetron hydrochloride 0,64 mg/ml
Injection Dacarbazine 8 mg/ml
Injection Doxorubicin hydrochloride 0,8 mg/ml
7 Day
  Mentions Légales