Last update :
18/04/2024
References   References 258  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/51/7/901

Research teams : Worcester - University of Massachusetts Medical Center, Department of pharmacy
Authors : Belliveau PP, Nightingale CH, Quintiliani R.
Title : Stability of aztreonam and ampicillin sodium-sulbactam sodium in 0.9% sodium chloride injection.
Reference : Am J Hosp Pharm ; 51: 901-904. 1994

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
InjectionAmpicillin sodium - sulbactam sodium Antibiotic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 20 mg/ml 24°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 20 mg/ml 5°C Not specified
60 Hour
InjectionAztreonam Antibiotic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 10 mg/ml 24°C Not specified
4 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 10 mg/ml 5°C Not specified
4 Day
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 24°C Not specified
Injection Aztreonam 10 mg/ml
Injection Ampicillin sodium - sulbactam sodium 20 mg/ml
24 Hour
Polyvinyl chloride Sodium chloride 0,9% 5°C Not specified
Injection Ampicillin sodium - sulbactam sodium 20 mg/ml
Injection Aztreonam 10 mg/ml
84 Hour

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