Last update :
12/06/2024
References   References 2531  
Type : Journal
Web link : https://doi.org/10.1177/1078155220918025

Research teams : Meldola - Oncology Pharmacy Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Italy
Authors : Sanogo S, Silimbani P, Gaggeri R, Masini C.
Title : Stability of calcium levofolinate reconstituted in syringes and diluted in NaCl 0.9% and glucose 5% polyolefin/ polyamide infusion bags.
Reference : J Oncol Pharm Practice ; 27, 2: 288-296. 2021

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionLevofolinate calcium Cytoprotective
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 1,7 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polypropylen Syringe Water for Injection 10 mg/ml 2-8°C Protect from light
14 Day

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