Last update :
28/04/2024
References   References 25  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/50/7/1410

Research teams : Omaha - University of Nebraska Medical center, College of pharmacy
Authors : McGuire TR, Narducci WA, Fox JL.
Title : Compatibility and stability of ondansetron hydrochloride, dexamethasone, and lorazepam in injectable solutions.
Reference : Am J Hosp Pharm ; 50: 1410-1414. 1993

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0,28 & 0,34 mg/ml + InjectionOndansetron hydrochloride 0,14 & 0,45 mg/ml + NaCl 0,9% or Glucose 5%
InjectionLorazepam Anxiolytic
Factors which affect stability Container Polyvinyl chloride Induces Adsorption
InjectionOndansetron hydrochloride Antiemetic
Compatible 0,14 & 0,45 mg/ml + InjectionDexamethasone sodium phosphate 0,28 & 0,34 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 25°C Light
Injection Ondansetron hydrochloride 0,14 & 0,45 mg/ml
Injection Dexamethasone sodium phosphate 0,34 mg/ml
24 Hour
Glass Glucose 5% 25°C Light
Injection Lorazepam 0,028 mg/ml
Injection Ondansetron hydrochloride 0,44 mg/ml
Injection Dexamethasone sodium phosphate 0,28 mg/ml
24 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
Injection Dexamethasone sodium phosphate 0,28 mg/ml
Injection Ondansetron hydrochloride 0,14 & 0,45 mg/ml
24 Hour

  Mentions Légales