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References   References 2435  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/53/19/2304
Research teams : Oklahoma City - University of Oklahoma Health Sciences Center, College of Pharmacy
Authors : Allen LV, Jr, Erickson MA,
Title : Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride, and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids
Reference : Am J Health-Syst Pharm ; 53: 2304-2309. 1996
Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
List of drugs
Oral solutionHydrochlorothiazide Diuretic
Oral solutionLabetalol hydrochloride Beta-blocker
Stability in solutions Plastic bottle Tablets 4800 mg
Normodyne®
OraPlus® / OraSweet® (1:1) >> 120 ml
25°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 4800 mg
Normodyne®
OraPlus® / OraSweet SF® (1:1) >> 120 ml
25°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 4800 mg
Normodyne®
Cherry syrup / Simple syrup (1:4) >> 120 ml
25°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 4800 mg
Normodyne®
OraPlus® / OraSweet® (1:1) >> 120 ml
5°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 4800 mg
Normodyne®
OraPlus® / OraSweet SF® (1:1) >> 120 ml
5°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 4800 mg
Normodyne®
Cherry syrup / Simple syrup (1:4) >> 120 ml
5°C Protect from light
60 Day
Oral solutionMetoprolol tartrate Anti-arrhythmic
Stability in solutions Plastic bottle Tablets 1200 mg
®=? (Mylan Pharmaceutical)
OraPlus® / OraSweet® (1:1) >> 120 ml
25°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 1200 mg
®=? (Mylan Pharmaceutical)
OraPlus® / OraSweet SF® (1:1) >> 120 ml
25°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 1200 mg
®=? (Mylan Pharmaceutical)
Cherry syrup / Simple syrup (1:4) >> 120 ml
25°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 1200 mg
®=? (Mylan Pharmaceutical)
OraPlus® / OraSweet® (1:1) >> 120 ml
5°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 1200 mg
®=? (Mylan Pharmaceutical)
OraPlus® / OraSweet SF® (1:1) >> 120 ml
5°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 1200 mg
®=? (Mylan Pharmaceutical)
Cherry syrup / Simple syrup (1:4) >> 120 ml
5°C Protect from light
60 Day
Oral solutionSpironolactone Diuretic
Oral solutionVerapamil hydrochloride Vasodilator
Stability in solutions Plastic bottle Tablets 6000 mg
®=? (Schein Pharmaceutical)
OraPlus® / OraSweet® (1:1) >> 120 ml
25°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 6000 mg
®=? (Schein Pharmaceutical)
OraPlus® / OraSweet SF® (1:1) >> 120 ml
25°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 6000 mg
®=? (Schein Pharmaceutical)
Cherry syrup / Simple syrup (1:4) >> 120 ml
25°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 6000 mg
®=? (Schein Pharmaceutical)
OraPlus® / OraSweet® (1:1) >> 120 ml
5°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 6000 mg
®=? (Schein Pharmaceutical)
OraPlus® / OraSweet SF® (1:1) >> 120 ml
5°C Protect from light
60 Day
Stability in solutions Plastic bottle Tablets 6000 mg
®=? (Schein Pharmaceutical)
Cherry syrup / Simple syrup (1:4) >> 120 ml
5°C Protect from light
60 Day
Stability of mixtures
Plastic bottle OraPlus® / OraSweet® (1:1) 120 ml
 25°C Protect from light
Oral solution Spironolactone Tablets ®=? (Mylan Pharmaceutical) 600 mg
Oral solution Hydrochlorothiazide Tablets ®=? (Mylan Pharmaceutical) 600 mg
60 Day
Plastic bottle OraPlus® / OraSweet SF® (1:1)  120 ml
 25°C Protect from light
Oral solution Spironolactone Tablets ®=? (Mylan Pharmaceutical) 600 mg
Oral solution Hydrochlorothiazide Tablets ®=? (Mylan Pharmaceutical) 600 mg
60 Day
Plastic bottle Cherry syrup / Simple syrup (1:4) 120 ml
 25°C Protect from light
Oral solution Spironolactone Tablets ®=? (Mylan Pharmaceutical) 600 mg
Oral solution Hydrochlorothiazide Tablets ®=? (Mylan Pharmaceutical) 600 mg
60 Day
Plastic bottle OraPlus® / OraSweet® (1:1) 120 ml
 5°C Protect from light
Oral solution Spironolactone Tablets ®=? (Mylan Pharmaceutical) 600 mg
Oral solution Hydrochlorothiazide Tablets ®=? (Mylan Pharmaceutical) 600 mg
60 Day
Plastic bottle OraPlus® / OraSweet SF® (1:1)  120 ml
 5°C Protect from light
Oral solution Hydrochlorothiazide Tablets ®=? (Mylan Pharmaceutical) 600 mg
Oral solution Spironolactone Tablets ®=? (Mylan Pharmaceutical) 600 mg
60 Day
Plastic bottle Cherry syrup / Simple syrup (1:4) 120 ml
 5°C Protect from light
Oral solution Hydrochlorothiazide Tablets ®=? (Mylan Pharmaceutical) 600 mg
Oral solution Spironolactone Tablets ®=? (Mylan Pharmaceutical) 600 mg
60 Day
  Mentions Légales